User blog comment:MarkoSeke/How to legitimately kill Twins, Destroyer or Skeleton Prime?/@comment-4123347-20111208144501

I think that the best strategy for The Destroyer would be to use a spear or a powerful sword, and use a gun or a bow to kill the probes as soon as they appear.

But I haven't been actually able to actually do it. I'd like to help you if you'd like though :)