User blog comment:O Terraria Wiki/how to defeat the wins in terraria/@comment-24021074-20140317111911/@comment-24133975-20140317202754

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 * You should try to avoid fighting both Twins in their second form at the same time. Try to kill them off one at a time. Since Spazmatism is statistically the deadliest of the two, you may wish to begin by eliminating it.
 * Caution is advised when fighting at high altitudes where the Wyvern can spawn.
 * Play the game on a high resolution or in full screen so that you can see The Twins from further away. This can help you to predict their movement patterns more easily.
 * Because Retinazer (Second Form) never attempts to use a melee attack and will not fire at you unless it has a clear line of sight, once Spazmatism is beaten you can build a small "box" with an opening and shoot at Retinazer with protection from most shots.
 * Take extreme caution when fighting both Retinazer and Spazmatism in their second forms; Spazmatism's cursed flame breath combined with Retinazer's laser attacks can kill you off fairly quickly. Using ranged means of attacks are recommended, as well as good armor.