Debuffs

 are a feature first introduced in patch 1.0.6. bestow negative effects upon their bearers, and, unlike buffs, cannot be removed by right-clicking on their icons. There are several accessories which provide immunity to a single Debuff, which build into the Ankh Charm, giving immunity to many debuffs. Some monsters can be infected with certain debuffs, including Confused, Cursed Inferno, On Fire! and Poisoned.

will naturally wear off after a short period of time, though some may last up to a few minutes. The Nurse can cure debuffs at the cost of  per debuff.

Table
undefinedThe following monsters can inflict the On Fire! debuff: Fire Imp (Burning Sphere), Lava Slime, Meteor Head, Skeleton Archer (Flaming Arrows)

undefinedThe following weapons can inflict the On Fire! debuff: Fiery Greatsword, Flamarang, Flamelash, Flamethrower, Flaming Arrow, Flower of Fire, Molten Fury, Molten Hamaxe, Molten Pickaxe, Sunfury

undefinedThe following weapons can inflict the Poisoned debuff: Blade of Grass, Poisoned Knife, Thorn Chakram, Tonbogiri.

undefinedThe following healing items will inflict the Potion Sickness debuff: Bottled Water, Glowing Mushroom, Goldfish, Greater Healing Potion, Healing Potion, Lesser Healing Potion, Lesser Restoration Potion, Mushroom, Restoration Potion

Bugs

 * When curing the Potion Sickness debuff via the Nurse, the icon disappears but the actual effects of the debuff are not removed.