Guide Voodoo Doll

The Guide Voodoo Doll is an accessory that can be dropped by a Voodoo Demon in the Underworld. It has a resemblance to the Guide.

When this item is equipped as an accessory, it becomes possible to kill the Guide with weapons. If the item is destroyed by Lava in the Underworld, it will kill the guide and summon the Wall of Flesh. If the item is destroyed while there is no living Guide, the Wall of Flesh will not appear.

Before the Wall of Flesh is defeated, the Arms Dealer's dialogue is replaced with the line "I heard there is a doll that looks very similar to [Name of Guide] somewhere in the underworld. I'd like to put a few rounds in it.", hinting at the fact the doll has to be destroyed to continue progression. The Nurse will occasionally say, "How many times will [Name of Guide] come in with severe lava burns?", hinting that the doll has to be thrown in lava. The [Name of Guide] sometimes will say, "When you are ready to challenge the keeper of the underworld, you will have to make a living sacrifice. Everything you need for it can be found in the Underworld", also hinting the [Name of Guide] will be sacrificed and that the doll needed for the sacrifice is found in the underworld.

Regardless if the Wall of Flesh is killed or not, the Guide will always respawn after being killed.

Trivia

 * When the player receives the On Fire! debuff, the sprite that appears resembles the guide in flames, foreshadowing the events that are required to summon the Wall of Flesh