Frostburn

Frostburn debuff causes you to lose 6 life per second and negates health regen. No enemies inflict this debuff. It is very useful early to mid-game, as only 7 enemies are immune to it.

Immune NPCs
Bosses:
 * The Destroyer
 * Mourning Wood
 * Duke Fishron

Other:
 * Hellhound
 * Ice Elemental
 * Ice Golem
 * Giant Cursed Skull