User blog comment:CaptainLocoMoco/Please help me figure out how to kill the destroyer!/@comment-4664776-20111210002128

Clockwork Assault Rifle and potions: Thorns x 5 Ironskin x 3 Gravitational x 4 Health Regeneration x 3 Crystal Bullets x 1250

Plenty of accessories with good bonuses. Especially ones that add to defense.