Guide:The Twins strategies

When fighting The Twins, it is perhaps best to focus on taking one down as quickly as possible rather than spreading damage between them. Each part has its own life gauge and eliminating one makes killing the other much easier.

Spazmatism is probably the easiest to kill first as it chases the player at the same level. Retinazer chases the player above the player, necessitating leading adjustments if using ranged weapons (which you'll probably use as both hit for significant damage in melee.) Just aim parallel to the ground and you can easily pump Spazmatism with arrows or shots.

However, even though Spazmatism is easier to hit initially, his second form may be harder to fight for some due to its constant chasing of the players with both it's flamethrower-like attack and its charging attack which is the most damaging move The Twins have. As such, choosing to eliminate Retinazer first may prove to be the more beneficial option as one may have an easier time avoiding Spazmatism's later attacks if Retinazer is already gone.

A wide-open, flat area is recommended for the fight for ease of evasion. If the ground is level enough to run across, it's possible to just kite the bosses with bow-/gunfire by running and simply shooting them as they give chase. Mobility is key. Rocket Boots, Spectre Boots, Angel Wings and/or Demon Wings are recommended.

If possible, a Megashark with Crystal Bullets make this a much easier fight (along with a ranged-type armor set). You need to kill The Destroyer first to get the Megashark, however.