Guide:Brain of Cthulhu strategies

Fighting the Brain of Cthulhu is very similar to fighting the Eye of Cthulhu, If you have the basics of how to Fight the Eye of Cthulhu, then you will have a better chance fighting the Brain.

The Area
You'll want to set up a large platform over The Crimson, for he can only spawn in there, regardless of day or night. It should be high enough so ground enemy's can't jump up to you, but low enough that you don't jump out of the crimson and make him despawn.

The Setup
If you want to stand a chance against the Brain of Cthulhu, you're going to need at least Iron or Lead armor, About 5 Healing Potions, 1 Ironskin Potion, 1 Regeneration Potion, and a Cloud in a Bottle (optional, but it helps when he lunges). As for weapons, use ranged or magic, only use melee if you feel over prepared and like a badass. for ranged bows, you're going to want to get a Silver Bow or Tungsten Bow or better with Flaming arrows. for ranged guns, you are going to want to find an Under Taker from Demon Hearts, the equivalent to the Shadow Orb in the Crimson. then buy lots and lots of musket rounds. for ranged thrown, get lots of Shurikens or Throwing Knifes. As for the Magic users, craft a Sapphire Staff or better when fighting him, and get at least 100 mana if you don't want to continually run out and hope that one of the orbiting eyes drop another star.