Ichor (debuff)

Ichor is a debuff that lowers the afflicted entity's defense by 15 /  20. It is inflicted by the ranged attack of an Ichor Sticker found in the Underground Crimson or by the Tainted Ghoul found in Crimson Underground Deserts in Hardmode. It can also be inflicted by weapons and the ammo crafted with Ichor.

Tips

 * Because of its effect, it is useful even in late-game, since barely any enemies are resistant to it. It is especially useful against enemies with high defense (e.g. Skeletron Prime (especially during head-spins), Paladins, Duke Fishron, etc.)
 * A common tactic is to use an Ichor-inflicting weapon on an enemy, and then finish it off with the player's main weapon.

Trivia

 * The damage increase from Ichor changes depending on the difficulty; It will increase the effective damage by 8 on Classic, 11 on Expert, and 15 on Master mode. This is due to how the effectiveness of defense changes with the difficulty, getting stronger as it gets harder.

History
Ichor (débuff) 灵液（减益）