User blog comment:SilverHexxitFights/Which is Terraria's Hardest Boss?/@comment-7842889-20131113030345

None of these bosses give me any trouble since I use Vampire Knives, so I never go below 460 health. I think that if you don't have anything like the Vampire Knives, then The Twins would have to be the hardest. With Plantera, all you need to do is make a fairly open space with platforms and your fine. The Twins are just so fast that it's sometimes hard to hit them, especially with green crap in your face dealing lots of damage. For killing any bosses, all you need is some okay defense armor, Vampire Knives, and a Cross Necklace.