Encumbering Stone

The Encumbering Stone is a pre-Hardmode item that prevents item pickup while inside the character's inventory. It is sometimes found in Sandstone Chests in the Underground Desert.

While in the inventory, the Encumbering Stone will prevent the pickup of any items, even if you already have a stackable item in your inventory. This can be very useful while farming events or mining out hellevators. The Encumbering Stone will also prevent the entry of items into Void Bags.

Items reeled in from fishing are still placed in the player's inventory. Hearts and Stars will also be picked up even with the Encumbering Stone in the inventory.

Trivia

 * The tooltip for the item is likely a reference to the warning text that appears in some RPGs (such as in  series) when the character is carrying more than they can lift.