Guide:Skeletron Prime strategies

Skeletron Prime is an absurdly difficult boss with high damage, HP, and defense values. It is best to prepare thoroughly ahead of time.

Equipment
If possible, a Megashark with Crystal Bullets make this a much easier fight (along with a ranged-type armor set). You need to kill The Destroyer first to get the Megashark. If attempting to fight Skeletron Prime alone, it is recommended you stick to ranged weaponry to better avoid Skeletron Prime's attacks. Rocket Boots, Spectre Boots, Angel Wings and/or Demon Wings are recommended for increased mobility. If no Angel/Demon Wings are available, be sure to equip a Lucky Horseshoe or an Obsidian Horseshoe to negate fall damage from the heights you can reach. You can also use a Featherfall Potion, or Gravitation Potion to compensate. It is also recommended that you have at least mythril armor before attempting the fight.