Potion Sickness

Potion Sickness is a debuff which is applied when the player heals with an item. It prevents the player from consuming any more healing items until the debuff times out.

Its duration can be reduced to 45 seconds by equipping the Philosopher's Stone or the Charm of Myths.

Trivia

 * Some players consider this the most annoying debuff in all of Terraria.
 * The name appears to be a pun on "Motion Sickness"