Board Thread:New on Terraria Wiki/@comment-24136903-20131106094355/@comment-24657342-20140309073006

it depends on your armour and your weapons, i personaly think that the destroyer is the easiest then the twins and skeletron prime is the hardest. for the destroyer: melee use a weapon like the dao of pow. ranged: use a gun with bullets that hit more than once(meteor shot or something like crystal bullets since they kinda like explode, ichor bullets are also an option since they decrease his defence) magic: use a spell like golden shower or demon scythe(any other spell that hits more than once should do the trick.

for the twins i strongly recommend ranged(melee is almost impossible and magic is a waste of mana pots) just make a bridge with lots of heart statues(wired to a 1second times) and switch them of with bonfires. all you need to do is run while shooting and then to the other side again.

for skeltron prime i have no idea which is the best(still trying to kill it)