Encumbering Stone

The Encumbering Stone is a pre-hardmode item that prevents item pickup while placed inside the player's inventory.

It can be obtained from looting Sandstone Chests in the Underground Desert.

Trivia

 * The tooltip for the item is likely a reference to the same text that appears in some Role-Playing games (such as in The Elder Scrolls series) when the player character is carrying more than they can lift.