Talk:The Twins/@comment-4246239-20111205003244

Due to their defense of 10, the Minishark will have trouble making a dent in their armor. However, the Megashark and Flamethrower may very well be 2 of the best weapons to use against them due to their insane DPS against enemies with armor this low. However, they require Souls dropped from either the Destroyer or Skeletron Prime, so you may have to look for other alternatives.

Other recommended weapons to use against them may include other high-damage-per-shot, rapid-fire weapons, such as the Phoenix Blaster, Clockwork Assault Rifle, Adamantite Repeater, Star Cannon, and Crystal Storm.