Mana Sickness

Mana Sickness is a debuff that reduces the player's magic damage by 25% after they drink any Mana Potion. The percentage of damage reduction is reduced by 5% every second, wearing off after 5 seconds have passed. If the player drinks additional Mana Potions while the debuff is active, the duration will be increased by 5 seconds for every drink, increasing the damage reduction accordingly up to a maximum of 50% at 10 seconds. Automatically drinking Mana Potions with the Mana Flower will still cause the debuff. The damage reduction appears to affect total magic damage, which means if you have +100% damage from buffs and items, the total damage with the debuff will be 200% * 0.75 = 150%.