User blog comment:Shadowfury2.0/the battle begins/@comment-4721962-20120207142817/@comment-4721962-20120207162826

@Squazzil The first hard mode boss that I defeated was the Twins, so that is my reasoning. Now that you mention it, it probably is easier to defeat the destroyer in his position. But like I said, I have an easier time with the Twins. (I'm sure someone would say that they can defeat Skeletron Prime easier than defeating the Destroyer, but that is just the way it is.)

Note to everyone else: Since everyone is different, remember that some suggestions (like mine) could just be based on their personal experience, and you might have a harder time.