Debuffs

 are a feature first introduced in patch 1.0.6. bestow negative effects upon their bearers, and unlike Buffs, cannot be removed by right-clicking on their icons. There are several accessories which provide immunity to a single Debuff, which build into the Ankh Charm, giving immunity to many debuffs. Some Monsters can be infected with certain debuffs, including Confused, Cursed Inferno, On Fire! and Poisoned.

will naturally wear off after a short period of time, though some may last up to a few minutes. The Nurse can cure debuffs at the cost of  per debuff.

In 1.2, many new accessories were added which prevent one specific debuff each, and can be combined at a Tinkerer's Workshop to create versions that give immunity to all the debuffs of their components.

Bugs

 * When curing the Potion Sickness debuff via the Nurse, the icon disappears but the actual effects of the debuff are not removed.
 * The Bleeding effect can be overridden by the Campfire effect.
 * While under the Frozen effect, player's social clothes might disappear. [Needs Confirmation]