User blog comment:TerrariaAsk/Terraria Questions and Answers/@comment-26885668-20150813161835

Well, as of what I heard about Duke Fishron, the best idea is to farm Ocram for Souls of Blight, use them to make gear, and also retrieve at least a Nights Edge. But a Death Sickle should be useful, along with 20 Greater Healing Potions.