Holy Hand Grenade

The Holy Hand Grenade is a thrown explosive that is an upgraded version of Dynamite, with more range and double the explosive radius (about 15 tiles).

Like Dynamite, it destroys blocks, with the exception of Dungeon Bricks, Lihzahrd Bricks, Cobalt, Palladium, Mythril, Orichalcum, Adamantite, Titanium, Hellstone (before defeating Wall of Flesh), Demon Altars, and any type of Chest (including Barrels and Trash Cans) if it has an item in it.

Trivia

 * It is a reference to the "holy hand grenade" from "Worms" (as it plays the same sound when throwing it), which is a reference to the 1975 film Monty Python and the Holy Grail, where Saint Attila requested God to bless a grenade, becoming the "Holy Hand Grenade of Antioch".
 * It's currently the item with highest base damage in Terraria, but is only available on the.
 * Though it's named a "Grenade", it explodes blocks like a Bomb.
 * Up until the Hardmode Update, it was in the game but couldn't be obtained without hacks.