User blog comment:TerrariamcSwaggins/Hey guys, what do you think is the best endgame Armor/Weapon combo in Terraria/@comment-1466854-20131111070109

Shroomite (helmet for rocket boost) and Stynger. Bolts can be purchased affordably, so no hassle with ammo upkeep, can wipe out massive swarms of enemies or do obscene damage to bosses, and you can't hurt yourself with it, unlike other rockets. I personally prefer to wear sniper scope, moon charm, star veil, ankh shield, and hoverboard for standard use, but I generally carry master ninja gear and a destroyer emblem with me as well to swap out when I want. The beauty of shroomite is that it also significantly boosts the megashark, piranha gun, sniper rifle, and plenty of other such fun weapons.

Though to be honest, though I prefer stynger as my end-all weapon for anything major, I rarely use it on standard mobs. For those, even wearing shroomite, I generally just stick to vampire knives. Lazy and effective, no sense wasting good ammo on squishy mobs. All five keyed weapons are part of my standard loadout and get used as secondary weapons.