User blog comment:Bacon mincher/please help!/@comment-1172471-20120118004424

Here is how i went

Skeleton Prime Destroyer of Words The Twins

You have access to Greater healing Potions so craft them. Pixie Dust and Crystals are common

Buffs: Bowl of Soup Archery Potion Thorns Potion Swiftness Potion Regen Potion Hunter Potion Grav Potion Ironskin Potion

Accessories: Angry Philosopher's Stone Warding Cross Necklace Armored Obsidian Shield Armored Spectre Boots Warding Angel Wings

Skeleton Prime: Armor: Adamantine Helmet, Adamantine Breastplate, Adamantine Leggings Weapons: Star Cannon, Adamantite Repeater, Clockwork Assault Rifle Ammo: Cursed Arrow, Cursed Bullet

Destroyer Of Worlds: Armor: Adamantine Mask, Adamantine Breastplate, Adamantine Leggings Weapon: Deadly Flamethrower Ammo: Gel

The Twins: Armor: Adamantine Helmet, Adamantine Breastplate, Adamantine Leggings Weapon: Megashark Ammo: Crystal Bullets (A godsend for this boss)

This is what i went and it worked well for me. Starting out is a pain but once you get Skeletron soul's it will get easier from there.