User blog comment:Turbogoggles/Boss Among Bosses/@comment-5420865-20120818022747/@comment-4301259-20120818041205

Use the Megashark only, and the following potions/buffs: Gravitation Potion, Bowl of Soup, Ironskin Potion, Regeneration Potion, and Thorns Potion.

Just keep flying around with the gravitation buff and it's not that hard. It's only time consuming. Cursed Bullets are fine, but Crystal Bullets are better against Skeletron Prime.