User blog comment:CaptainLocoMoco/Please help me figure out how to kill the destroyer!/@comment-4648910-20111210105724

The best option is to gather some friends together or find a server or others who are looking for the same sort of thing. You need fairly high level gear as the destroyer is an upgraded boss and will be a lot more tougher than the previous bosses like the normal eater of worlds. Rather than melee weapons, I find range weapons equipped with jester arrows are the best way to go. Only melee weapon I can recommand is Dark Lance or higher - (spears only, as they will go through multiple segments and deal more damage). This also works with weapons such as sunfury but is more fiddly to fight with. Armour wise, at least molten or better. All up the best advice is that you have to be fairly skilled and used to terraria.