Debuffs

Debuffs are temporary, negative status effects. Unlike Buffs, they cannot be cancelled by right-clicking their icons.

Most debuffs can only be inflicted by enemies, on players. Players can inflict the following debuffs on enemies: Confused, Cursed Inferno, Ichor, Midas, Poisoned, Venom, On Fire!, Frostburn and Shadowflame. Players can also inflict Bleeding on enemies via the console/mobile-exclusive Tizona.

In general, damaging debuffs will stack: If you are both Poisoned and On Fire!, you will take damage from both of them. However, Poisoned and Venom do not stack, and Poisoned will take precedence over Venom. Death always cancels any active buffs or debuffs. Buffs on the other hand, affect the player positively while they are taking effect.

The Nurse can cancel debuffs at a cost of  per active debuff.

Triva
The Moon Bite debuff is the only debuff with a different colored background. It's light blue instead of red.

History
디버프 Débuff Дебаффы