Skeletron Prime

Skeletron Prime is a harder version of Skeletron that was released in the 1.1 update. It has four arms, different weapons on each, such as a claw, chainsaw, cannon and one that shoots laser beams. It has a total of 30,000 health.

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When fighting for the first time, at least 2 people are recommended due to the difficulty of the boss. However, that isn't to say that destroying Skeletron Prime solo isn't possible.

Skeletron Prime is summoned with the Mechanical Skull during nighttime, regardless of the zone you are currently in. Meaning that, similar to the Suspicious Looking Eye, your location is irrelevant.

Tips

 * When the Skeletron Prime uses its spin attack, metal spikes come out of its head.
 * It's possible to destroy each of Skeletron Prime's hands, like the current Skeletron, although it is not recommended as they each have 7000 hp each.
 * You should have: Full set of Adamantite Armor or Hallowed Armor*, 2000+ (1000 is not enough for cursed with 2000 you'll have about 500 left if you shoot good) Cursed Bullets or 1500+ Crystal bullets, use Megashark only Megashark other weapons are hard to use you can use other guns but have some skills! Ironskin Potions, nice large arena (if not using Gravitation Potions - 3+ Wooden Platforms in the air, vertical from each other going up and down, each about 25+ platforms long and several dart traps 30 blocks high from platform at both ends activated by 3 second repeater ) 30 Healing Potions, Thorns Potions, Philosopher's Stone and a Cobalt Shield or the improved version Obsidian Shield . *If second time fighting.
 * One of the easiest ways of defeating Skeletron Prime is to only aim for his head. This makes the boss fight alot more accomplishable for the first time as the arms of Skeletron Prime have 7000 health each and are just not worth wasting time on.
 * By putting the Nurse at your spawn point, you'll be able to teleport there and heal whenever needed - provided you don't fight too far away from it. This also works with The Twins and The Destroyer.