Talk:Hard Mode/@comment-26406968-20160222064523/@comment-4511886-20160222105338

The Twins are pretty much the simplest, since the fight is basically just two Eyes of Cthulu with increased range. Ranged attacks with a high DPS weapon like the Clockwork Assault Rifle or something similar should work wonders.

Skeletron Prime is awfully similar to Skeletron, the only real difference being the two extra ranged attacks. If you take down those arms, it will be pretty similar to a standard Skeletron fight.