User blog comment:ZombieARCY/Pumping up for the Bosses!/@comment-5144388-20130504212241

A repeating swinging sword from Hard Mode will do you good for the Destroyer. For the Twins, focus on a single eye. For Skeletron Prime, focus on the saw and the lasers. Then onto the head.

Completed Twins with Megashark, 500 Silver Bullets.

Completed the Destroyer with Tizona, Dao of Pow and Magical Harp.

Completed Skeletron Prime with Shotgun, 500 Silver Bullets, Tizona, Hallowed Repeater, 500 Unholy Arrows.

Completed Ocram with Megashark, 500 Silver Bullets, Tizona, Light Disk and Magical Harp.

Completed Wall of Flesh with Minishark, 500 Meteor Shots, Phoenix Blaster, same amount of ammo, Night's Edge and Sharanga, 500 Wooden Arrows (Sharanga turns all arrows into Specteral Arrows)

Hoped this guide helped, I also don't want to make it look like I have bragged.