If left alone for a short while, it will charge at the player extremely fast, becoming virtually unstoppable. This is presumed to be a bug.
New players should be cautious around the Antlion Charger as its high health and knockback resistance make it significantly more difficult to kill than an Antlion. As well as this, its high speed makes it difficult to escape by running horizontally. As they are very large, a thin vertical shaft (e.g. 2 tiles wide) can be used to escape or to fight from with ranged weapons.
Despite their high damage and resilience, they can easily be trapped, especially in the Underground Desert. The very small gaps between caves there means that weapons can damage them but they cannot escape, allowing them to be easily farmed, even by early-game players.
This allows for easy farming of their drops, including the Mandible Blade, a formidable early game, autoswing sword, and the Banana Split, a food item.
Due to the large number of small pockets in the Underground Desert, players will often be able to see where the charger is and the space it is able to move in before they have to face it. This makes it possible to come up with a strategy before fighting, or avoid it entirely.
Strangely, the Antlion Charger's attack decreases Expert post-Plantera, rather than increasing.