The Lucky Horseshoe can be very handy when exploring chasms, as the player will not need to worry about being damaged from long vertical drops.
Once the player has found a Grappling Hook and/or a Cloud in a Bottle, the Lucky Horseshoe loses some of its usefulness, and can potentially be swapped out, although having one equipped is always a good safeguard, as the Grappling Hook can take some time to retract, and the Cloud in a Bottle can only be used once per fall. A set of wings seems to remove any and all usefulness of this item, saving the player an accessory slot, as it also negates fall damage completely, but Lucky Horseshoes can be accessed much sooner than all but one of the different wing types, seeing as most wings can only be obtained in Hardmode.
Trivia[]
It is possible for a Lucky Horseshoe to generate or be reforged with the modifier "Lucky", giving it the name "Lucky Lucky Horseshoe". A similar trick can be done with the Deadly Sphere Staff, Lucky Coin and Arcane Flower.