The Tissue Sample is a crafting material only obtainable by fighting the Brain of Cthulhu and its Creeper minions. Tissue Samples are ingredients in most Crimtane Tier equipment. Tissue samples are The Crimson equivalent to Shadow Scales.

You will need 61 Tissue Samples to craft all the items — 45 for the full armor set and 16 for the Deathbringer PickaxeFlesh Grinder and The Meatball.

Update Info


  • Added to the game.